Photoredox halogenation of quinolones: the dual role of halo-fluorescein dyes?
Organic & Biomolecular Chemistry Pub Date: 2021-04-20 DOI: 10.1039/D1OB00538C
Abstract
An efficient C-3 halogenation of quinolin-4-ones is reported with halogenated fluorescein dyes which serve both as a halogen source and photocatalyst. This reaction shows broad substrate scope and gives good to excellent yields of C-3 brominated/iodinated quinolones with eosin Y/rose bengal in green light under ambient conditions. The mechanistic investigations suggest a radical pathway involving the oxidative dehalogenation of the dye in the presence of air.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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