• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
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• 2. Excited-state proton-coupled electron transfer within ion pairs?
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• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
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• 4. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
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• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
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4-Bromo-2,6-Bis(Bromomethyl)Pyridine (CAS No. 106967-42-4)

4-Bromo-2,6-bis(bromomethyl)pyridine, also known by its CAS registry number CAS 106967-42-4, is a highly specialized organic compound with significant applications in various fields of chemistry. This compound belongs to the class of brominated pyridines, which are known for their unique chemical properties and reactivity. The molecule features a pyridine ring with bromine substituents at positions 2 and 6, as well as a bromomethyl group at position 4. This specific substitution pattern imparts distinctive electronic and steric properties to the molecule, making it valuable in both academic research and industrial applications.

The synthesis of 4-bromo-2,6-bis(bromomethyl)pyridine typically involves multi-step organic reactions, often starting from pyridine derivatives. The introduction of bromine substituents is achieved through electrophilic substitution reactions, which are facilitated by the electron-deficient nature of the pyridine ring. The bromomethyl groups are introduced via alkylation reactions, which require precise control of reaction conditions to ensure regioselectivity and yield optimization. Recent advancements in catalytic methods and transition metal-mediated reactions have significantly improved the efficiency of these synthesis pathways.

In terms of physical properties, 4-bromo-2,6-bis(bromomethyl)pyridine is a crystalline solid with a melting point of approximately 150°C. Its molecular weight is around 315 g/mol, and it is sparingly soluble in common organic solvents such as dichloromethane and ethyl acetate. The compound exhibits strong UV absorption characteristics due to the conjugated π-system of the pyridine ring, which makes it useful in photochemical applications.

The chemical reactivity of 4-bromo-2,6-bis(bromomethyl)pyridine is primarily influenced by the electron-withdrawing effects of the bromine substituents. These groups deactivate the pyridine ring towards nucleophilic aromatic substitution but activate it towards electrophilic substitution under certain conditions. The bromomethyl groups also contribute to the compound's reactivity by providing potential sites for further functionalization through nucleophilic attack or elimination reactions.

Recent studies have explored the use of 4-bromo-2,6-bis(bromomethyl)pyridine as a versatile building block in medicinal chemistry. Researchers have employed this compound to synthesize bioactive molecules with potential applications in cancer therapy and anti-inflammatory treatments. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit significant inhibitory activity against certain kinases involved in cellular signaling pathways.

In addition to its role in drug discovery, 4-bromo-2,6-bis(bromomethyl)pyridine has found applications in materials science. Its ability to coordinate with metal ions has led to its use in the synthesis of metal-organic frameworks (MOFs) and coordination polymers. These materials exhibit high surface areas and porosity, making them promising candidates for gas storage and catalytic applications.

The environmental impact and safety profile of CAS 106967-42-4 have also been subjects of recent research. Studies have focused on its biodegradation pathways and potential toxicity to aquatic organisms. Results indicate that while the compound exhibits moderate toxicity under acute exposure conditions, it undergoes rapid degradation under aerobic conditions, reducing its long-term ecological impact.

In conclusion, 4-bromo-2,6-bis(bromomethyl)pyridine (CAS No. 106967-42-4) is a versatile compound with a wide range of applications across multiple disciplines. Its unique chemical properties make it an invaluable tool in both academic research and industrial processes. As ongoing studies continue to uncover new uses for this compound, its significance in the field of organic chemistry is expected to grow further.

• 64114-29-0(2-(Bromomethyl)-6-methylpyridine hydrobromide)
• 7703-74-4(2,6-Bis(bromomethyl)pyridine)
• 5093-70-9(4-Bromo-2,6-dimethylpyridine)
• 55401-97-3(2-(Bromomethyl)pyridine)
• 145218-19-5(5-Bromo-2-(bromomethyl)pyridine)
• 31106-82-8(2-(bromomethyl)pyridine;hydrobromide)
• 68470-59-7(2-(Bromomethyl)-6-methylpyridine)
• 22282-99-1(4-Bromo-2-methylpyridine)
• 856834-97-4(4-BROMO-2-METHYL-PYRIDINE HYDROCHLORIDE)
• 73004-40-7(Pyridine, 2,6-bis(bromomethyl)-, hydrobromide)