• 1. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 2. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993
• 3. An automated in-chip-catalytic–spectrophotometric method for determination of copper(ii) using a multisyringe flow injection analysis-multipumping flow system?
  Camelia Henríquez,Edwin Palacio,Víctor Cerdà Anal. Methods, 2014,6, 8494-8504
• 4. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 5. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Methylpyridines

Professional Introduction to 2-(Bromomethyl)-6-methylpyridine hydrobromide (CAS No. 64114-29-0)

2-(Bromomethyl)-6-methylpyridine hydrobromide, with the chemical formula C?H?Br?N, is a significant compound in the field of pharmaceutical and chemical research. This compound, identified by its CAS number 64114-29-0, has garnered attention due to its versatile applications in the synthesis of various bioactive molecules. The presence of both a bromomethyl group and a methyl-substituted pyridine ring makes it a valuable intermediate in the development of pharmaceutical agents, particularly those targeting neurological and inflammatory disorders.

The< strong> bromomethyl functionality in 2-(Bromomethyl)-6-methylpyridine hydrobromide allows for further functionalization through nucleophilic substitution reactions, enabling the creation of complex molecular structures. This property is particularly useful in medicinal chemistry, where such intermediates serve as building blocks for drug candidates. The< strong> hydrobromide salt form enhances the stability and solubility of the compound, making it more accessible for synthetic applications.

In recent years, there has been a growing interest in exploring the potential of 2-(Bromomethyl)-6-methylpyridine hydrobromide in the development of novel therapeutic agents. For instance, studies have highlighted its role in the synthesis of kinase inhibitors, which are crucial in treating various cancers and inflammatory diseases. The pyridine core is a common pharmacophore in many drugs, and modifications at the 2-position can significantly alter the biological activity of the molecule.

One notable application of this compound is in the synthesis of neurological drugs. The bromomethyl group can be selectively coupled with amines or thiols to generate more complex structures that interact with specific neurotransmitter receptors. Recent research has demonstrated promising results in using derivatives of 2-(Bromomethyl)-6-methylpyridine hydrobromide to develop treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's. These studies leverage the compound's ability to modulate receptor activity and inhibit pathological protein aggregation.

The< strong> pharmaceutical industry has also explored this compound for its potential in creating anti-inflammatory agents. Pyridine derivatives are known for their ability to interact with various inflammatory pathways, and modifications at key positions can enhance their efficacy. In particular, studies have shown that compounds derived from 2-(Bromomethyl)-6-methylpyridine hydrobromide can inhibit cyclooxygenase (COX) enzymes, which are pivotal in the production of prostaglandins that mediate inflammation.

In addition to its pharmaceutical applications, 2-(Bromomethyl)-6-methylpyridine hydrobromide has found utility in materials science. The bromomethyl group allows for polymerization reactions, making it a potential monomer for creating novel polymers with specific properties. These polymers could find applications in coatings, adhesives, and even advanced materials for electronics.

The synthesis of 2-(Bromomethyl)-6-methylpyridine hydrobromide typically involves the bromination of 6-methylpyridine using brominating agents such as N-bromosuccinimide (NBS). This reaction introduces the bromomethyl group at the 2-position of the pyridine ring. The subsequent formation of the hydrobromide salt is achieved by treating the free base with hydrobromic acid (HBr). This synthetic route is efficient and scalable, making it suitable for industrial production.

Ongoing research continues to uncover new applications and derivatives of 2-(Bromomethyl)-6-methylpyridine hydrobromide. For example, recent studies have investigated its use as a precursor for metal-organic frameworks (MOFs), which are highly porous materials with potential applications in catalysis, gas storage, and separation technologies. The versatility of this compound underscores its importance as a building block in synthetic chemistry.

The< strong> safety profile of 2-(Bromomethyl)-6-methylpyridine hydrobromide is another critical aspect that has been extensively studied. While handling this compound requires standard laboratory precautions due to its reactivity, it does not pose significant health hazards when used appropriately. Proper storage conditions and handling procedures ensure that its benefits can be maximized while minimizing any potential risks.

In conclusion, 2-(Bromomethyl)-6-methylpyridine hydrobromide (CAS No. 64114-29-0) is a multifaceted compound with broad applications in pharmaceuticals, materials science, and chemical research. Its unique structure and reactivity make it an invaluable intermediate for synthesizing bioactive molecules and advanced materials. As research continues to evolve, new applications and derivatives of this compound are likely to emerge, further solidifying its importance in scientific innovation.

• 337508-56-2(1-(Bromomethyl)isoquinoline hydrobromide)
• 79313-01-2(2-(Bromomethyl)-4,6-dimethylpyridine)
• 7703-74-4(2,6-Bis(bromomethyl)pyridine)
• 55401-97-3(2-(Bromomethyl)pyridine)
• 31106-82-8(2-(bromomethyl)pyridine;hydrobromide)
• 74417-44-0(1-(Bromomethyl)isoquinoline)
• 68470-59-7(2-(Bromomethyl)-6-methylpyridine)
• 91458-11-6(Pyridine,2,4-bis(bromomethyl)-6-methyl-)
• 1032650-53-5(4-bromo-2-(bromomethyl)pyridine)
• 73004-40-7(Pyridine, 2,6-bis(bromomethyl)-, hydrobromide)