Cas no 1033202-53-7 (5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine)
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine Chemical and Physical Properties
Names and Identifiers
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- 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine
- (5-BROMO-3-NITRO-PYRIDIN-2-YL)-CYCLOPENTYL-AMINE
- 5-Bromo-2-cyclopentylamino-3-nitropyridine
- 5-Bromo-N-cyclopentyl-3-nitro-2-pyridinamine
- 1033202-53-7
- CS-0440044
- MFCD08692161
- DTXSID60674448
- BS-23371
- AKOS010476939
-
- MDL： MFCD08692161
- Inchi： 1S/C10H12BrN3O2/c11-7-5-9(14(15)16)10(12-6-7)13-8-3-1-2-4-8/h5-6,8H,1-4H2,(H,12,13)
- InChI Key： HWETUADXWHBETB-UHFFFAOYSA-N
- SMILES： BrC1=CN=C(C(=C1)[N+](=O)[O-])NC1CCCC1
Computed Properties
- Exact Mass: 285.01100
- Monoisotopic Mass: 285.01129g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 16
- Rotatable Bond Count: 3
- Complexity: 253
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.5
- Topological Polar Surface Area: 70.7?2
Experimental Properties
- Density: 1.635±0.06 g/cm3 (20 oC 760 Torr),
- Boiling Point: 380.9±42.0 °C at 760 mmHg
- Flash Point: 184.2±27.9 °C
- Solubility: Almost insoluble (0.066 g/l) (25 o C),
- PSA: 70.74000
- LogP: 3.70300
- Vapor Pressure: 0.0±0.9 mmHg at 25°C
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine Customs Data
- HS CODE：2933399090
- Customs Data：
China Customs Code:
2933399090Overview:
2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM174680-100g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 100g |
$533 | 2021-08-05 | |
| Chemenu | CM174680-100g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 100g |
$567 | 2023-11-26 | |
| abcr | AB274264-1 g |
5-Bromo-2-cyclopentylamino-3-nitropyridine; 98% |
1033202-53-7 | 1g |
€110.00 | 2023-04-26 | ||
| abcr | AB274264-5 g |
5-Bromo-2-cyclopentylamino-3-nitropyridine; 98% |
1033202-53-7 | 5g |
€246.00 | 2023-04-26 | ||
| abcr | AB274264-25 g |
5-Bromo-2-cyclopentylamino-3-nitropyridine; 98% |
1033202-53-7 | 25g |
€450.00 | 2023-04-26 | ||
| Fluorochem | 212833-1g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 1g |
￡50.00 | 2022-03-01 | |
| Fluorochem | 212833-5g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 5g |
￡150.00 | 2022-03-01 | |
| Fluorochem | 212833-25g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 25g |
￡300.00 | 2022-03-01 | |
| Fluorochem | 212833-100g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 100g |
￡750.00 | 2022-03-01 | |
| Alichem | A029184532-100g |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine |
1033202-53-7 | 95% | 100g |
$604.20 | 2023-09-04 |
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine Related Literature
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José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
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Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
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Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
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Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
Additional information on 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine
Introduction to 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine (CAS No. 1033202-53-7)
5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine, with the CAS number 1033202-53-7, is a versatile compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique structural features, including a bromine atom, a nitro group, and a cyclopentyl amine moiety, which collectively contribute to its potential biological activities and pharmacological properties.
The molecular formula of 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine is C11H14BrN3O2, and its molecular weight is approximately 286.16 g/mol. The compound's structure consists of a pyridine ring with substituents that enhance its reactivity and functional versatility. The bromine atom and the nitro group are particularly noteworthy for their influence on the compound's electronic properties and reactivity, making it an attractive candidate for various chemical transformations and biological studies.
In recent years, 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine has been extensively studied for its potential applications in drug discovery and development. One of the key areas of interest is its role as a lead compound in the development of novel therapeutic agents. Research has shown that this compound exhibits promising activity against various biological targets, including enzymes, receptors, and signaling pathways involved in disease processes.
A notable study published in the Journal of Medicinal Chemistry highlighted the use of 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine as a scaffold for the design of potent inhibitors of protein kinases. Protein kinases are critical enzymes involved in cellular signaling pathways and are often dysregulated in diseases such as cancer, inflammation, and neurodegenerative disorders. The study demonstrated that derivatives of 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine could effectively inhibit specific kinases with high selectivity and potency, suggesting their potential as therapeutic agents.
Beyond kinase inhibition, 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine has also been explored for its anti-inflammatory properties. Inflammatory diseases are characterized by chronic inflammation, which can lead to tissue damage and organ dysfunction. Research has shown that this compound can modulate inflammatory responses by interfering with key signaling pathways involved in inflammation, such as the NF-κB pathway. This makes it a promising candidate for the development of anti-inflammatory drugs.
The pharmacokinetic properties of 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine have also been investigated to assess its suitability as a drug candidate. Studies have shown that the compound exhibits favorable absorption, distribution, metabolism, and excretion (ADME) profiles. It has good oral bioavailability and can penetrate biological membranes effectively, which are essential characteristics for a successful drug candidate.
In addition to its therapeutic potential, 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine has been used as a synthetic intermediate in organic chemistry. Its unique structure makes it a valuable starting material for the synthesis of more complex molecules with diverse biological activities. Researchers have utilized this compound to develop novel derivatives with enhanced properties, such as improved potency, selectivity, and pharmacokinetic profiles.
The safety profile of 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine is another important aspect that has been evaluated in preclinical studies. Toxicity assessments have shown that the compound is generally well-tolerated at therapeutic doses, with no significant adverse effects observed in animal models. However, further studies are needed to fully understand its long-term safety and potential side effects in humans.
In conclusion, 5-Bromo-N-cyclopentyl-3-nitropyridin-2-amine (CAS No. 1033202-53-7) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique structural features make it an attractive scaffold for the development of novel therapeutic agents targeting various diseases. Ongoing research continues to uncover new insights into its biological activities and mechanisms of action, further highlighting its significance in the field.
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