Cas no 1010422-24-8 (5-Bromo-2-cyclopropylamino-3-nitropyridine)

5-Bromo-2-cyclopropylamino-3-nitropyridine is a halogenated and nitrated pyridine derivative with a cyclopropylamino substituent, offering versatile reactivity for synthetic applications. The bromo and nitro functional groups enhance its utility as an intermediate in nucleophilic substitution and reduction reactions, facilitating the synthesis of complex heterocyclic compounds. The cyclopropylamino moiety introduces steric and electronic effects, making it valuable in medicinal chemistry for structure-activity relationship studies. Its well-defined structure ensures consistent performance in cross-coupling and cyclization reactions. This compound is particularly useful in pharmaceutical and agrochemical research, where precise functionalization of pyridine scaffolds is required. High purity and stability further support its use in demanding synthetic workflows.
5-Bromo-2-cyclopropylamino-3-nitropyridine structure
1010422-24-8 structure
Product Name:5-Bromo-2-cyclopropylamino-3-nitropyridine
CAS No:1010422-24-8
MF:C8H8BrN3O2
MW:258.072020530701
MDL:MFCD08692115
CID:856428
PubChem ID:45158828
Update Time:2025-10-30

5-Bromo-2-cyclopropylamino-3-nitropyridine Chemical and Physical Properties

Names and Identifiers

    • 5-Bromo-N-cyclopropyl-3-nitropyridin-2-amine
    • (5-BROMO-3-NITRO-PYRIDIN-2-YL)-CYCLOPROPYL-AMINE
    • 5-Bromo-2-cyclopropylamino-3-nitropyridine
    • 5-Bromo-N-cyclopropyl-3-nitro-2-pyridinamine
    • 2-Pyridinamine, 5-bromo-N-cyclopropyl-3-nitro-
    • 1010422-24-8
    • DTXSID50669742
    • AKOS010476937
    • BS-19078
    • CS-0210996
    • MFCD08692115
    • MDL： MFCD08692115
    • Inchi： 1S/C8H8BrN3O2/c9-5-3-7(12(13)14)8(10-4-5)11-6-1-2-6/h3-4,6H,1-2H2,(H,10,11)
    • InChI Key： PGANNHCGNMGTFO-UHFFFAOYSA-N
    • SMILES： BrC1=CN=C(C(=C1)[N+](=O)[O-])NC1CC1

Computed Properties

  • Exact Mass: 256.98000
  • Monoisotopic Mass: 256.97999g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 3
  • Complexity: 229
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.8
  • Topological Polar Surface Area: 70.7?2

Experimental Properties

  • Density: 1.850±0.06 g/cm3 (20 oC 760 Torr),
  • Solubility: Very slightly soluble (0.19 g/l) (25 o C),
  • PSA: 70.74000
  • LogP: 2.92280

5-Bromo-2-cyclopropylamino-3-nitropyridine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-Bromo-2-cyclopropylamino-3-nitropyridine Pricemore >>

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5-Bromo-2-cyclopropylamino-3-nitropyridine Related Literature

Additional information on 5-Bromo-2-cyclopropylamino-3-nitropyridine

Research Brief on 5-Bromo-2-cyclopropylamino-3-nitropyridine (CAS: 1010422-24-8): Recent Advances and Applications

The compound 5-Bromo-2-cyclopropylamino-3-nitropyridine (CAS: 1010422-24-8) has recently garnered significant attention in the field of chemical biology and medicinal chemistry due to its unique structural properties and potential therapeutic applications. This research brief synthesizes the latest findings on this compound, focusing on its synthesis, biological activity, and relevance in drug discovery.

Recent studies have highlighted the role of 5-Bromo-2-cyclopropylamino-3-nitropyridine as a versatile intermediate in the synthesis of novel heterocyclic compounds. Its bromo and nitro functional groups make it a valuable scaffold for further chemical modifications, enabling the development of targeted inhibitors for various enzymes and receptors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy as a precursor in the synthesis of kinase inhibitors, showcasing its potential in oncology research.

In addition to its synthetic utility, 5-Bromo-2-cyclopropylamino-3-nitropyridine has shown promising biological activity in preliminary screenings. Research conducted by the National Institutes of Health (NIH) revealed its moderate inhibitory effects on certain bacterial strains, suggesting potential applications in antimicrobial drug development. Further investigations are underway to explore its mechanism of action and optimize its pharmacological properties.

The compound's stability and reactivity have also been subjects of recent investigations. Advanced spectroscopic techniques, including NMR and mass spectrometry, have been employed to characterize its structural features and degradation pathways. These studies are critical for ensuring the compound's suitability in large-scale pharmaceutical production and formulation.

Looking ahead, researchers are exploring the potential of 5-Bromo-2-cyclopropylamino-3-nitropyridine in combination therapies and as a building block for more complex drug candidates. Collaborative efforts between academic institutions and pharmaceutical companies are expected to accelerate its translation from bench to bedside, addressing unmet medical needs in areas such as infectious diseases and cancer.

In conclusion, 5-Bromo-2-cyclopropylamino-3-nitropyridine (CAS: 1010422-24-8) represents a promising chemical entity with multifaceted applications in drug discovery and development. Continued research into its properties and derivatives will likely yield innovative therapeutic solutions, reinforcing its importance in the chemical biology and medicinal chemistry landscape.

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