• 1. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 2. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 3. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 4. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 5. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetamides

Recent Advances in the Study of 2-(4-(Dimethylamino)phenyl)acetohydrazide (CAS: 100133-14-0) in Chemical Biology and Pharmaceutical Research

The compound 2-(4-(Dimethylamino)phenyl)acetohydrazide (CAS: 100133-14-0) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential therapeutic applications and unique chemical properties. This research briefing aims to provide a comprehensive overview of the latest findings related to this compound, focusing on its synthesis, biological activity, and potential applications in drug development.

Recent studies have highlighted the role of 2-(4-(Dimethylamino)phenyl)acetohydrazide as a key intermediate in the synthesis of various pharmacologically active molecules. Its structural features, including the dimethylamino group and the hydrazide moiety, make it a versatile building block for the development of novel therapeutic agents. Researchers have explored its utility in the design of antimicrobial, anticancer, and anti-inflammatory compounds, with promising results in preclinical models.

One of the most notable advancements in this area is the discovery of the compound's ability to modulate specific biological pathways. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of 2-(4-(Dimethylamino)phenyl)acetohydrazide exhibit potent inhibitory effects on certain enzymes involved in inflammatory responses. This finding opens new avenues for the development of anti-inflammatory drugs with improved efficacy and reduced side effects.

In addition to its therapeutic potential, recent research has also focused on optimizing the synthesis of 2-(4-(Dimethylamino)phenyl)acetohydrazide to enhance yield and purity. Advanced techniques such as microwave-assisted synthesis and green chemistry approaches have been employed to achieve these goals, as reported in a 2024 article in Organic Process Research & Development. These methodological improvements are critical for scaling up production and ensuring the compound's availability for further research and development.

Another area of interest is the compound's potential role in targeted drug delivery systems. Preliminary studies suggest that 2-(4-(Dimethylamino)phenyl)acetohydrazide can be functionalized to create prodrugs or conjugates that enhance the specificity and bioavailability of therapeutic agents. This approach is particularly relevant in the context of cancer therapy, where targeted delivery can minimize off-target effects and improve patient outcomes.

Despite these promising developments, challenges remain in the clinical translation of 2-(4-(Dimethylamino)phenyl)acetohydrazide-based therapies. Issues such as pharmacokinetics, toxicity, and formulation stability need to be addressed through further research. Collaborative efforts between academic institutions and pharmaceutical companies are essential to overcome these hurdles and bring these innovations to the market.

In conclusion, 2-(4-(Dimethylamino)phenyl)acetohydrazide (CAS: 100133-14-0) represents a promising candidate for various therapeutic applications, with recent research underscoring its versatility and potential. Continued exploration of its biological activities and optimization of its synthesis will be crucial for unlocking its full potential in the pharmaceutical industry. This briefing highlights the importance of ongoing research and collaboration to advance the field and deliver impactful solutions to unmet medical needs.

• 103-81-1(2-Phenylacetamide)
• 3335-98-6(1-Phenyl-1,3-dihydro-2H-indol-2-one)
• 86-86-2(1-Naphthylacetamide)
• 90-93-7(4,4'-Bis(diethylamino)benzophenone)
• 530-44-9(4-(Dimethylamino)benzophenone)
• 59-48-3(Oxindole)
• 2124-31-4(4'-Dimethylaminoacetophenone)
• 90-94-8(4,4'-Bis(dimethylamino)benzophenone)
• 100-10-7(p-Dimethylaminobenzaldehyde)
• 102-93-2(3-Phenylpropanamide)