Chiral peptide nucleic acid monomers (PNAM) with modified backbones?

Organic & Biomolecular Chemistry Pub Date: 2008-07-09 DOI: 10.1039/B806141F

Abstract

Convenient high yielding syntheses of optically pure PNAMs comprising L- or D-serine, L-lysine and L-arginine units linked to thymine or Cbz-cytosine are described. Simple workup and inexpensive reagents are employed and free amino acids are used as coupling components.

Graphical abstract: Chiral peptide nucleic acid monomers (PNAM) with modified backbones
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