A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines?

Chemical Communications Pub Date: 2014-07-23 DOI: 10.1039/C4CC04940C

Abstract

Rh-catalysed conjugate additions of 2-aminophenyl boronic acid derivatives were exploited in diastereoselective and asymmetric syntheses of tetrahydroquinolines. In both cases, combinatorial variation of the substitution of the tetrahydroquinoline ring system was possible.

Graphical abstract: A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines
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