Clathrates of TETROL: selective inclusion of methylcyclohexanones in their energetically unfavorable axial methyl conformations?

Chemical Communications Pub Date: 2014-09-18 DOI: 10.1039/C4CC06826B

Abstract

3- and 4-Methylcyclohexanone have been isolated exclusively as their energetically disfavoured axial conformers in the host–guest complexes formed upon recrystallization of the novel optically pure host compound, (+)-(2R,3R)-1,1,4,4-tetraphenylbutane-1,2,3,4-tetraol (TETROL), from these cycloalkanones.

Graphical abstract: Clathrates of TETROL: selective inclusion of methylcyclohexanones in their energetically unfavorable axial methyl conformations
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