C–C and C–X coupling reactions of unactivated alkyl electrophiles using copper catalysis
Chemical Society Reviews Pub Date: 2020-05-27 DOI: 10.1039/D0CS00316F
Abstract
Transition metal-catalysed cross-coupling reactions are widely used for construction of carbon–carbon and carbon–heteroatom bonds. However, compared to aryl or alkenyl electrophiles, the cross-coupling of unactivated alkyl electrophiles containing β hydrogens remains a challenge. Over the past few years, the use of suitable ligands such as bulky phosphines or N-heterocyclic carbenes (NHCs) has enabled reactions of unactivated alkyl electrophiles not only limited to the traditional cross-coupling with Grignard reagents, but also including a diverse range of organic transformations via either SN2 or radical pathways. This review provides a comprehensive overview of the recent development in copper-catalysed C–C, C–N, C–B, C–Si and C–F bond-forming reactions using unactivated alkyl electrophiles.
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Journal Name：Chemical Society Reviews
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CAS no.: 89640-58-4
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