Cascade polycyclisations in natural product synthesis

Organic & Biomolecular Chemistry Pub Date: 2011-04-28 DOI: 10.1039/C1OB05212H

Abstract

The efficient, stereocontrolled construction of polycyclic ring systems has long presented a formidable challenge to synthetic chemists. Cascade reactions offer a ‘quick fix’—building multiple rings in a single step—and often dramatically shorten a synthetic route. In this Emerging Area article, a selection of the most recent and impressive examples of applications of this tactic to natural product synthesis are discussed, which demonstrate the ambition and achievements of the modern synthetic chemist.

Graphical abstract: Cascade polycyclisations in natural product synthesis
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