Catalyst-free cyclization of anthranils and cyclic amines: one-step synthesis of rutaecarpine?
Chemical Communications Pub Date: 2019-09-13 DOI: 10.1039/C9CC06160F
Abstract
An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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