Carbon nanotube-mediated delivery of budesonide to macrophages?
RSC Advances Pub Date: 2016-05-20 DOI: 10.1039/C6RA09809F
Abstract
Carbon nanotubes were functionalized with budesonide, a potent anti-inflammatory drug, and investigated for interactions with macrophages. Pristine carbon nanotubes were first shortened to make them compatible with cellular dimensions before budesonide was non-covalently appended to their surface via a specifically designed amphiphilic molecule. The resulting nanohybrids were evaluated in regards to their internalisation into macrophages and ability to inhibit pro-inflammatory cytokine secretion. In vitro experiments showed that the budesonide delivery system is readily captured by phagocytic cells and has a deep anti-inflammatory effect as it strongly inhibits IL-6 production.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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