C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis?
Chemical Science Pub Date: 2021-01-07 DOI: 10.1039/D0SC05409G
Abstract
Efficient C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles have been developed. The former route enables C4-arylation in a highly efficient and mild manner and the latter route provides an alternative straightforward protocol for synthesis of C2/C4 disubstituted indoles. The mechanism studies imply that the different reaction pathways were tuned by the distinct acid additives, which led to either the Pd(I)–Pd(II) pathway or Pd(II) catalysis.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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