A Cu-catalyzed practical approach to α-ketoesters under air: an efficient aerobic oxidative dehydrogenative coupling of alcohols and α-carbonyl aldehydes?
Organic Chemistry Frontiers Pub Date: 2014-01-08 DOI: 10.1039/C3QO00041A
Abstract
A novel and efficient approach to α-ketoesters has been developed with wide functional group tolerance. This copper-catalyzed oxidative dehydrogenative coupling reaction of alcohols and α-carbonyl aldehydes employs air as the oxidant and generates H2O as the only by-product. Broad substrate scope, high atom economy and mild reaction conditions make this chemistry very practical.
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Journal Name：Organic Chemistry Frontiers
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