Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio?

Chemical Communications Pub Date: 2006-11-07 DOI: 10.1039/B614446B

Abstract

The chiral diphosphinite ligand derived from (R)-1,1′-spirobiindane-7,7′-diol has been found to be highly effective in the Ir-catalyzed asymmetric hydrogenation of quinolines with high substrate/catalyst ratio (up to 5000) and high enantioselectivity (up to 94% ee).

Graphical abstract: Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio
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