Bioinspired photocatalysed C–H fluoroalkylation of arenes in water promoted by native vitamin B12 and Rose Bengal?
Green Chemistry Pub Date: 2021-09-07 DOI: 10.1039/D1GC02654B
Abstract
The first perfluoroalkylation reaction of activated arenes (amino-substituted arenes and alkoxyarenes) has been achieved in water by employing the dyad Rose Bengal and hydrosoluble unmodified vitamin B12 (cyanocobalamin) as the photocatalyst and co-catalyst, respectively. The reaction was performed under green LED irradiation and employed perfluoroalkyl bromides as the perfluoroalkyl radical sources. In particular, the presence of vitamin B12 co-catalyst was found to be fundamental to elicit the formation of perfluoroalkyl radicals.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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