Base promoted highly efficient copper fluorapatite catalyzed coupling of phenols with arylboronic acids under mild and ligand-free conditions

RSC Advances Pub Date: 2012-10-19 DOI: 10.1039/C2RA21850J

Abstract

A mild, general and highly efficient protocol has been developed for the synthesis of diaryl ethers in good to excellent yield under mild and ligand-free conditions. This is the first example in which a recyclable, heterogeneous copper fluorapatite catalyst is used for the arylation of phenols with arylboronic acids at room temperature in the presence of Cs2CO3 as a base and methanol as a solvent. The catalyst was recovered and reused several times without loss of catalytic activity.

Graphical abstract: Base promoted highly efficient copper fluorapatite catalyzed coupling of phenols with arylboronic acids under mild and ligand-free conditions
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