Biomimetic trifunctional organocatalyst showing a great acceleration for the transesterification between vinyl ester and alcohol?

Chemical Communications Pub Date: 2008-01-22 DOI: 10.1039/B718763G

Abstract

Trifunctional organocatalysts 1a and 1b mimicking the active site of serine hydrolases showed high catalytic activity with up to a 3 700 000-fold acceleration for the acyl-transfer reactions from vinyl trifluoroacetate to alcohol.

Graphical abstract: Biomimetic trifunctional organocatalyst showing a great acceleration for the transesterification between vinyl ester and alcohol
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