A convergent strategy towards febrifugine and related compounds?
Organic & Biomolecular Chemistry Pub Date: 2018-05-15 DOI: 10.1039/C8OB00935J
Abstract
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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