Design and syntheses of some iminosugar derivatives as potential immunosuppressants?
MedChemComm Pub Date: 2011-07-08 DOI: 10.1039/C1MD00098E
Abstract
Eleven new iminosugar derivatives were synthesized and the effects of these synthetic iminosugars on proliferation of the mouse splenocytes were evaluated by the cell counting kit-8 (CCK-8) assay. The preliminary structure–activity relationships were deduced from the experimental data. It was found that iminosugar 14 (IC50 = 22 μM) and its C-5 epimer 15 (IC50 = 45 μM) displayed the strongest inhibitory effects, and might hold potential as
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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