Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors?

MedChemComm Pub Date: 2011-12-01 DOI: 10.1039/C1MD00219H

Abstract

The design and synthesis of a potent series of c-jun N-terminal kinase (JNK2) inhibitors is described. The development and optimization of the 2,4-diaminopyrimidines series was carried out from an earlier in-house kinase inhibitor program. Through the optimization of the scaffold 2, several cell potent compounds with good in vivo profiles were discovered.

Graphical abstract: Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
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