Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease?

MedChemComm Pub Date: 2012-03-23 DOI: 10.1039/C2MD20075A

Abstract

Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [18F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [18F]-fluoride), specific activities (>1 Ci μmol?1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.

Graphical abstract: Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease
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