Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity??

MedChemComm Pub Date: 2012-08-13 DOI: 10.1039/C2MD20162C

Abstract

Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.

Graphical abstract: Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity
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