The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout??
MedChemComm Pub Date: 2016-06-08 DOI: 10.1039/C6MD00191B
Abstract
A novel series of low molecular weight and synthetically facile acidic sulfonamides that are potent and selective URAT1 inhibitors is described. Compounds 46 and 47 were identified as promising leads from in vitro pharmacology and ADME profiling and advanced to broader in vitro and in vivo PK and toxicology studies.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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