In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy?
Photochemical & Photobiological Sciences Pub Date: 2019-01-11 DOI: 10.1039/C8PP00402A
Abstract
The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10?7 M, with minimal toxicity (89% cell viability) in the absence of light.
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Journal Name：Photochemical & Photobiological Sciences
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CAS no.: 89640-58-4
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