Production of indole antibiotics induced by exogenous gene derived from sponge metagenomes?
Molecular BioSystems Pub Date: 2015-03-25 DOI: 10.1039/C5MB00131E
Abstract
Sponge metagenomes are accessible genetic sources containing genes and gene clusters responsible for the biosynthesis of sponge-derived bioactive natural products. In this study, we obtained the clone pDC112, producing turbomycin A and 2,2-di(3-indolyl)-3-indolone, based on the functional screening of the metagenome library derived from the marine sponge Discodermia calyx. The subcloning experiment identified ORF 25, which is homologous to inosine 5′-monophosphate dehydrogenase and required for the production of 2,2-di(3-indolyl)-3-indolone in Escherichia coli.
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Journal Name：Molecular BioSystems
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CAS no.: 89640-58-4
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