A comparative study of lysosome-targetable pH probes based on phenoxazinium attached with aliphatic and aromatic amines?
Analyst Pub Date: 2016-03-21 DOI: 10.1039/C6AN00258G
Abstract
In this paper, phenoxazinium was used as a fluorophore for the design of pH probes by the photoinduced electron transfer (PET) mechanism. Phenoxazinium with an aliphatic morpholinyl group (probe 1a) gave increased emission at 665 nm with pH ranging from 7.4 to 4.4; meanwhile, the other one with an aromatic diethylaminophenyl group (probe 1b) gave nearly OFF–ON emission at 679 nm with pH ranging from 7.4 to 4.2. They both were reversible pH probes with good selectivity. Their optical properties, especially the PET mechanism, were illustrated by (TD)DFT theory. Fluorescence confocal imaging of probes 1a–b and a typical phenoxazinium dye (Oxazine 1) was also performed, and the results indicated that probes 1a–b are lysosome-targetable biomarkers.
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Journal Name：Analyst
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CAS no.: 89640-58-4
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