Synthesis and reactions with amines and ammonia of ethyl 3,4,5-trimethoxyphenylglycidate
Journal of the Chemical Society C: Organic Pub Date: DOI: 10.1039/J39690001991
Abstract
The synthesis of trans-ethyl 3,4,5-trimethoxyphenylglycidate (I) by the Darzens condensation is described and its configuration is deduced from n.m.r. analysis. The oxiran ring-opening reactions of (I) with alkylamines and ammonia in absolute ethanol were found to proceed with cleavage exclusively at the aryl-substituted oxiran carbon.
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Journal Name：Journal of the Chemical Society C: Organic
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CAS no.: 89640-58-4
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