Acyl trifluoroacetates. Part IV. Trifluoroacetylation of hydroxy-compounds with trifluoroacetic anhydride
Journal of the Chemical Society B: Physical Organic Pub Date: DOI: 10.1039/J29680000114
Abstract
Alcohols and phenols are trifluoroacetylated in carbon tetrachloride much more rapidly by trifluoroacetic anhydride than by acetyl trifluoroacetate. Pyridine bases are effective catalysts for the trifluoroacetylation of phenols but not of alcohols or thiophenol, and this effect is attributed to phenolic compounds showing greater nucleophilicity through hydrogen-bonding with the base.
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Journal Name：Journal of the Chemical Society B: Physical Organic
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CAS no.: 89640-58-4
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