Au(iii)-catalyzed ring opening reaction of 1-cyclopropyl-2-yn-1-ols with nucleophiles: highly efficient approach to (Z)-conjugated enynes?

New Journal of Chemistry Pub Date: 2007-11-08 DOI: 10.1039/B714511J

Abstract

A highly efficient approach to (Z)-conjugated enynes has been developed by utilizing an Au(III)-catalyzed ring opening reaction of 1-cyclopropyl-2-yn-1-ols with nucleophiles under mild conditions; the method is valuable due to the excellent yield and high regio- and stereoselectivity.

Graphical abstract: Au(iii)-catalyzed ring opening reaction of 1-cyclopropyl-2-yn-1-ols with nucleophiles: highly efficient approach to (Z)-conjugated enynes
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