Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720?

RSC Advances Pub Date: 2014-05-13 DOI: 10.1039/C4RA02401J

Abstract

A novel and efficient method for the selective monobenzoylation of N-Bz-FTY720 with benzoyl methyl phosphate (BMP) promoted by Zn(OAc)2 and Cs2CO3 was developed. Benzoyl methyl phosphate plays an important role as a biomimetic acylating agent for the monobenzoylation of 1,3-diols.

Graphical abstract: Benzoyl methyl phosphate as an efficient reagent for the selective monobenzoylation of N-Bz-FTY720
Recommended Literature