Enantioseparation of carbonyl compounds by high-performance liquid chromatography based on diastereomer formation
Analytical Proceedings including Analytical Communications Pub Date: DOI: 10.1039/AI9943100265
Abstract
The optically active fluorescent tagging reagents, 4-(2-carbazoylpyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole [R(+)-and S(–)-NBD-ProCZ] and 4-(2-carbazoylpyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole [R(+)-and S(–)-DBD-ProCZ], react with enantiomers of aldehydes and ketones under mild conditions (65 °C for 10 min) in the presence of trichloroacetic acid (TCA). Fluorescent hydrazone diastereomers derived from some chiral ketones were separated by reversed-phase and/or normal-phase high-performance liquid chromatography, on achiral columns.
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Journal Name：Analytical Proceedings including Analytical Communications
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CAS no.: 89640-58-4
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