Aqueous MW eco-friendly protocol for amino group protection?
RSC Advances Pub Date: 2015-02-09 DOI: 10.1039/C4RA16683C
Abstract
In this paper a new catalyst-free and on-water method for protection of amines and amino acids with di-tert-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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