Synthesis of warfarin analogs: conjugate addition reactions of alkenyl-substituted N-heterocycles with 4-hydroxycoumarin and related substrates?
RSC Advances Pub Date: 2023-02-06 DOI: 10.1039/D3RA00251A
Abstract
We have developed a procedure for the Michael addition of 4-hydroxycoumarins to vinyl-substituted N-heterocycles. The chemistry is also suitable for thiocoumarins and quinolinones. A mechanism is proposed involving nucleophilic attack at the vinyl-group of the protonated N-heterocycle.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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