An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to CO and CN bonds
Organic Chemistry Frontiers Pub Date: 2022-09-07 DOI: 10.1039/D2QO01209J
Abstract
Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first examples were reported 18 years ago by Akiyama and Terada. Although they were originally developed for enantioselective additions to imines, a wide reaction scope has been demonstrated using this type of catalyst. In this review, the known applications of CPA for enantioselective additions to C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
O and CN bonds are covered.
![Graphical abstract: An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to C [[double bond, length as m-dash]] O and C [[double bond, length as m-dash]] N bonds](http://scimg.chem960.com/usr/1/D2QO01209J.jpg)
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Journal Name：Organic Chemistry Frontiers
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