Cu-Catalyzed synthesis of spiroimidazole derivatives via an indolyl mediated cyclization–rearrangement reaction?
Organic Chemistry Frontiers Pub Date: 2022-09-09 DOI: 10.1039/D2QO01237E
Abstract
A novel Cu-catalyzed synthesis of structurally valuable spiroimidazole derivatives from 2-(indol-3-yl)cyclohexanones and amidines via an indolyl mediated cyclization–rearrangement reaction is described. The present approach features advantages including easily available starting materials, mild reaction conditions, gram-scale synthesis and high atom economy, providing convenient access to spiroimidazole derivatives.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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