Natural product total synthesis using rearrangement reactions
Organic Chemistry Frontiers Pub Date: 2022-08-06 DOI: 10.1039/D2QO01040B
Abstract
Total synthesis of natural products has been an important pursuit in chemical synthesis due to their fascinating structural complexity and/or interesting biological activities. In most synthetic designs, the rapid construction of the core skeletons, the precise control of stereochemistry, and the identification of suitable synthons are key concerns, which, to a large extent, account for the overall synthetic efficiency. This review will highlight how rearrangement reactions can contribute in addressing these three concerns, thus simplifying the total synthesis campaigns.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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