Manganese-mediated reductive N,N-dialkylation of nitroarenes: a dramatic NiI2 effect?
Organic Chemistry Frontiers Pub Date: 2022-07-26 DOI: 10.1039/D2QO00928E
Abstract
A practical method for the synthesis of N,N-dialkyl anilines via reductive dialkylation of nitroarenes has been developed. This protocol uses inexpensive substrates, and cheap NiI2 has been identified as the key promoter for the transformation. It features high functional group tolerance and can be applied for the formal synthesis and late-stage modification of drugs or pesticides. Preliminary mechanistic studies imply that aryl hydroxylamine might serve as the intermediate.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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