A convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines?
Organic & Biomolecular Chemistry Pub Date: 2022-08-10 DOI: 10.1039/D2OB01106A
Abstract
An oxidative amidation of 2-methylpyridines/2-methylbenzimidazole with amines using copper acetate and elemental sulfur in DMSO to afford various N-(hetero)arylamides has been accomplished. Mechanistic studies reveal the intermediacy of N-(pyridin-2-ylmethyl)aniline and confirm the role of DMSO as the oxygen source.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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