Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A?
Organic & Biomolecular Chemistry Pub Date: 2023-06-26 DOI: 10.1039/D3OB00836C
Abstract
Nucleoside analogs show useful bioactive properties. A versatile solid-phase synthesis that readily enables the diversification of thymine-containing nucleoside analogs is presented. The utility of the approach is demonstrated with the preparation of a library of compounds for analysis with SNM1A, a DNA damage repair enzyme that contributes to cytotoxicity. This exploration provided the most promising nucleoside-derived inhibitor of SNM1A to date with an IC50 of 12.3 μM.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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