A regioselective synthesis of β-difluoromethoxy vinyl sulfones via O-difluoromethylation of β-ketosulfones using sodium chlorodifluoroacetate?
Organic & Biomolecular Chemistry Pub Date: 2023-07-26 DOI: 10.1039/D3OB01142A
Abstract
A practical synthesis of new β-difluoromethoxy vinyl sulfones has been explored by O-difluoromethylation of β-ketosulfones using the inexpensive and easily workable sodium chlorodifluoroacetate as a difluorocarbene precursor. The strategy is convenient and regioselective, and features an adequate substrate scope and functional group tolerance.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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