Formal synthesis of cyclotheonellazole A?
Organic & Biomolecular Chemistry Pub Date: 2023-03-29 DOI: 10.1039/D3OB00038A
Abstract
A convergent procedure for the formal synthesis of cyclotheonellazole A in high yields and excellent stereoselectivity has been developed. This synthesis features an efficient preparation of O-pivaloyl-protected α-hydroxy-β-amino amides and a one-pot process to introduce the challenging thiazole moiety. The overall synthesis is very efficient and paves the way for the preparation of analogues for drug development.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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