A solvent controlled three-component reaction of diazo compounds for the synthesis of hydrazone compounds under Br?nsted acid catalysis?

New Journal of Chemistry Pub Date: 2022-11-23 DOI: 10.1039/D2NJ04983J

Abstract

A novel Br?nsted acid catalyzed three-component reaction of diazo compounds has been achieved from α-diazo ester, N-aminophthalimide and a solvent. An important feature of the method is that different products can be prepared selectively by modulating the reaction solvent. The reaction allows the synthesis of various amide hydrazone and α-hydroxyhydrazone products in moderate to good yield.

Graphical abstract: A solvent controlled three-component reaction of diazo compounds for the synthesis of hydrazone compounds under Br?nsted acid catalysis
Recommended Literature