Visible-light-induced tandem difluoroalkylated spirocyclization of N-arylpropiolamides: access to C3-difluoroacetylated spiro[4,5]trienones?
New Journal of Chemistry Pub Date: 2022-02-01 DOI: 10.1039/D2NJ00131D
Abstract
A visible-light-catalyzed difluoroacetylated spirocyclization of N-arylpropiolamides with ethyl bromodifluoroacetate as a CF2CO2Et radical precursor is described. This approach allows the formation of two carbon–carbon bonds and one carbon–oxygen bond in a single reaction through a sequence of C–H oxidative coupling, ipso-cyclization and dearomatization processes. This protocol affords a straightforward route to synthesize CF2CO2Et-containing spiro[4.5]trienones in moderate to good yields.
![Graphical abstract: Visible-light-induced tandem difluoroalkylated spirocyclization of N-arylpropiolamides: access to C3-difluoroacetylated spiro[4,5]trienones](http://scimg.chem960.com/usr/1/D2NJ00131D.jpg)
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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