Iron selenide nanorods for light-activated anticancer and catalytic applications?

New Journal of Chemistry Pub Date: 2022-12-27 DOI: 10.1039/D2NJ05094C

Abstract

Photoresponsive nanoparticles are capable of converting light energy into heat and generate reactive oxygen species (ROS) to exert a variety of applications. In this study, we report a simple approach for the synthesis of iron selenide nanorods (FeSe NRs) that show dual-applications, namely red laser-induced photothermal therapy (PTT) and ROS-induced photocatalysis. These NRs have a high visible and near-infrared (NIR) absorption and may be stimulated using a 635 nm red diode laser, resulting in a strong photothermal effect (ΔT = 15.5 °C). These NRs also show oxidase-like behavior in aqueous dispersion. Upon treatment of pancreatic cancer (Panc-I) cells with these NRs in vitro, followed by irradiation of light, substantial cell death occurred. Approximately 32% cell viability was observed at the optimum concentration of NRs. The laser-induced photocatalytic ability of these NRs has further been investigated. Photocatalytic dye degradation was attributed to both the oxidase-like behavior of the NRs and their ability to produce ROS. The degradation reaction follows first order kinetics with the rate constant of 0.389 s?1. These observations show that these NRs serve as a promising platform for phototherapeutic and photocatalytic applications.

Graphical abstract: Iron selenide nanorods for light-activated anticancer and catalytic applications
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