A cascade A3 coupling strategy towards the regioselective synthesis of β-carboline N-fused pyrrole derivatives with pyridine tethers?
New Journal of Chemistry Pub Date: 2022-12-01 DOI: 10.1039/D2NJ04620B
Abstract
A potential three component reaction strategy has been devised to generate nature inspired β-carboline N-fused pyrroles containing pyridine tethers. These scaffolds were afforded in high yields via a one-pot cascade regioselective reaction of diverse Kumujian C, 2-aminopyridines and alkyne derivatives under Cu(II)-catalysis. A library of 32 novel indolizino[8,7-b]indole derivatives with pyridine tethers has been developed. The current protocol offers excellent regioselectivity, high atom-economy and significant structural diversity.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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