Electrochemical radical–radical cross-coupling: direct access to β-amino nitriles from unactivated imines and alkyl nitriles?

Green Chemistry Pub Date: 2022-05-26 DOI: 10.1039/D2GC00457G

Abstract

In this article, a direct access to β-amino nitriles from unactivated imines and alkyl nitriles by electrochemical radical–radical cross-coupling was described for the first time. The use of abundant and inexpensive alkyl nitriles without pre-functionalization for the reductive cyanoalkylation of imines makes the reaction atom- and step-economical. This synthetic strategy provides a green, mild and efficient method for the construction of β-amino nitrile derivatives.

Graphical abstract: Electrochemical radical–radical cross-coupling: direct access to β-amino nitriles from unactivated imines and alkyl nitriles
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