A water-promoted catalytic hydrodecarboxylation of conjugated carboxylic acids under open air conditions at room temperature?
Green Chemistry Pub Date: 2023-03-30 DOI: 10.1039/D3GC00351E
Abstract
A water-promoted DABCO-organocatalyzed hydrodecarboxylation of conjugated carboxylic acids has been developed, providing the corresponding decarboxylation products in good to excellent yields. This metal-, photocatalyst-, and oxidant-free protocol features high functional group tolerance, wide substrate scope, gram-scale synthesis, and operational simplicity under open air conditions at room temperature. A trace amount of water as the hydrogen source for the successful conversion and the origin of the chemoselectivity are demonstrated through a series of control experiments.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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