Transition metal-free selective C–S bond cleavage of Ugi-adducts for rapid preparation of peptidomimetics?
Green Chemistry Pub Date: 2022-03-11 DOI: 10.1039/D1GC04421D
Abstract
A transition metal-free C–S bond cleavage and subsequent Mannich reaction of Ugi-adducts with alcohols as well as thiols is developed. Diverse novel peptidomimetics containing N,O- or N,S-aminals are synthesized in a rapid, highly efficient and step-economical fashion. This method features exclusive selectivity, broad substrate scope, excellent yield and functional group tolerance, and was applied on substrates derived from the pharmaceuticals febuxostat, probenecid and memantine.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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